Octavius is introduced in Spider-Man 2 as a nuclear physicist and friend and mentor of Peter Parker, whose research into fusion power with his wife Rosie (portrayed by Donna Murphy) is being sponsored by Oscorp's genetic and scientific research division, headed by Harry Osborn. Otto Gunther Octavius is a fictional character portrayed by Alfred Molina in Spider-Man 2 (2004) and later in the Marvel Cinematic Universe (MCU) film Spider-Man: No Way Home (2021), based on the Marvel Comics character of the same name. Alfred Molina ( SM2 film game, Spider-Man: Across the Spider-Verse (archive voice))įour robotic arms with artificial intelligence.